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Diogenes Santiago Santos

Diógenes Santiago Santos, Brazilian microbiologist, biochemist and molecular biologist (Gandu, Bahia State 28 June 1942 – Porto Alegre 23 June 2017)


Authored about 200 scientific works (with about 3,000 citations and h index 31)


Solved the three-dimensional structure of 39 proteins deposited in Protein Data Bank (PDB)

With I. Schrank, A. Zaha & E.F. Araújo. Construction of a gene library from Azospirillum brasilense and characterization of a recombinant containing the nif structural genes. Braz. J. Med. Biol. Research 20:321-30, 1988

With J.C.D. Hinton, A. Sarafi, J. Sidebotham, C. Higgins, T.A. Owenhughes & G.D. Pavitt. H-NS A Novel DNA-Binding Protein Involved in Maintaining Chromatin Structure and Regulating gene Expression. Journal of Cellular Biochemistry 8(Suppl.),  295-6, 1993

With J. Rakonjac, M. Milic, R. Ivanisevic & D. Savic. Nov a New Genetic Locus that Affects Response of Escherichia coli to Novobiocin. Molecular Microbiology, 6(11):1547-53, 1992

With A. H. R. Paz, S. Rief, E. Wolf, K. Prelle & E.O.C. Lima. Mouse embryonic stem cells: The establishment of the system to produce differentiated cell types in vitro. Acta Scientiae Veterinariae 31(1):51-4, 2003

With J.S. de Oliveira, L.A. Basso, M. Palaci, R. Dietze & I.S. Moreira. An inorganic iron complex that inhibits wild type and an isoniazid-resistant mutant 2 trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. Chemical Communications 3:312-3, 2004

With F. Canduri, V. Fadel, L. A. Basso, M.S. Palma & W.F. Azevedo Jr. New catalytic mechanism for human Purine nucleoside Phosphorilase. Biochemical and Biophysical Research Communications 327:646-9, 2005

With E.H. de Souza, D.L. Pontes, I.C. N. Diogenes, E. Longhinotti, L.G.F. Lopes, J.S. de Oliveira, L.A. Basso & I.S. Moreira. Electron Transfer Kinetics and Mechanism Study of the Thionicotinamide Coordinate to the Ironpentacyano (II) and (III) Complexes: A Model System for the in vitro Activation of Thioamides anti-tuberculosis drugs. Journal of Inorganic Biochemistry 99:368-75, 2005

With B.A.D Neto, F.S Mancilha, I.B. Vasconcelos, C. Thum, L.A. Basso & J. Dupont  New Sensitive Fluorophores for Selective DNA detection. Organic Letters 9:4001-4, 2007

With C.L. Fernandes, A. Breda, L.A. Basso & O.N. de Souza. A Structural Model for Chorismate Synthase from Mycobacterium tuberculosis in Complex with Coenzyme and Substrate. Computers in Biology and Medicine 37:149-58, 2007

With I.C. Werlang, C. Schneider & L.A. Basso. Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology 155:2652-63, 2009

With L.A. Basso, C.Z. Schneider, A. J. A. B. Santos & M.M. Campos. An inorganic Complex that Inhibits Mycobacterium tuberculosis Enoyl Reductase as a Prototype of a New Class of Chemotherapeutic Agents to Treat Tuberculosis. Journal of the Brazilian Chemical Society 7:1384-89, 2010

With E.H. de Souza, L.A. Basso, I.C.N. Diogenes, E. Longhinotti, L.G. F. Lopes & I. S. Moreira. Isoniazid metal complex reactivity and insights for a novel anti-tubercular drug. JBIC. Journal of Biological Inorganic Chemistry 17:275-83, 2012

With M.C de Moraes, R. G. Ducati, A.J. Donato, L.A. Basso, C.L. Cardoso & Q.B. Cass. Capillary bioractors based on human Purine Nucleoside Phosphorylase: a new approach for ligands indetification and characterization. Journal of Chromatography  1232:110-5, 2012

With I. Pauli, R.N. dos Santos, D.C. Rostirolla, L.K. Martinelli, R.G. Ducati, L.F.S. Timmers, L.A. Basso, R.V.C. Guido, A.D. Andricopulo & O.N. Souza. Discovery of New Inhibitors of Mycobacterium tuberculosis InhA Enzyme Using Virtual Screening and a 3D-Pharmacophore-Based Approach. Journal of Chemical Information and Modeling 53:2390-2401, 2013

With D. Renck, P. Machado, A.A. Souto, L.A. Rosado, T. Erig, M.M. Campos, C.B. Farias, R. Roesler, Luis F.S. Timmers, O.N. de Souza & L.A. Basso. Design of Novel Potent Inhibitors of Human Uridine Phosphorylase-1: Synthesis, Inhibition Studies, Thermodynamics, and in Vitro Influence on 5-Fluorouracil Cytotoxicity. Journal of Medicinal Chemistry 56:8892-02, 2013

With P. Machado, E. Ritter, A.J.B. dos Santos, C. Neves & L.A. Basso. Ultrasound-assisted improvement of drug solubility: a simple and useful method for the formation of salts from 4-hydroxy-6-methyl-3-nitropyridin-2(1H)-one. Monatshefte fur Chemie , 144:1165-70, 2013

With D. Renck, A. Santos Jr., P. Machado, G.O. Petersen, T. J. Lopes, M.M. Campos,  & L.A. Basso. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil induced intestinal mucosositis. Investigational New Drugs (2014)

With G.O. Petersen, S. Saxena, J. Renuka, V. Soni, P. Yogeeswari, C.V. Bizarro & D. Sriram. Structure-based virtual screening as a tool for the identification of novel inhibitors against Mycobacterium tuberculosis 3-dehydroquinate dehydratase. Journal of Molecular Graphics & Modelling , (2015)

With G. Cattaneo, D. Ubiali, E. Calleri, M. Rabuffetti, G.C. Höfner, K.T. wanner, M.C. de Moraes, L.K.B. Martinelli, G. Speranza & G. Massolini. Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase. Analytica Chimica Acta 943: 89-97, 2016

With T. Gazzi, M. Rotta, A. Villela, V. Rodrigues Jr., L. Martinelli, F. Sales, E. de Sousa, M. Campos, L.A. Basso & P. Machado. Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones. Journal of the Brazilian Chemical Society (2017)

With N.D.M. Sperotto, C.D. Roth, V.S. Rodrigues Jr., C.E. Neves et al. Design of novel inhibitors of human thymidine phosphorylase: synthesis, enzyme inhibition, in vitro toxicity and impact on human glioblastoma cancer. J. Med. Chem. 62(3):1231-45, 2019 


BRAZILIAN AND FOREIGN PATENTS

With P. Machado, L.A. Basso & K. Pissinate. Compound, method for producing the compound, pharmaceutical composition, use of the compound for preparing a medicinal drug for treating a disorder caused by bacteria of the genus Mycobacterium and method for treating a disorder caused by bacteria of the genus Mycobacterium BR1020150146809 & WO2016201541 A1 (2015)

With L.A. Basso, P. Machado & D. Renck. Uso de 6-hidroxi-2-piridonas e seus derivados na preparação de uma composição farmacêutica que atue pela inibição da enzima uridina fosforilase humana (Use of 6-hydroxy 2 pyridones and derivatives thereof for preparing a pharmaceutical composition that act by inhibiting the human uridine phosphorylase enzyme ) BR10 2013022567-3 A232 (2013) & US9700547B2 (2014)

With L.A. Basso, P. Machado & T.P. Gazzi. Method for synthesizing lanthanide-based coordination compounds, gadolinium (III)-based coordination compound and use of same BR102013023479-6 (2013) & WO2015035483A1 (2015) 

With E.L. Batista Jr., L.A. Basso, A.A. Souto, A.J. Donato & C. Deves. Deazapurinas, processo de preparo, composições farmacêuticas compreendendo deazapurinas e seu uso em osteoporose e/ou perda óssea, (Deazapurin, preparation process, pharmaceutical compositions, understanding deazapurin and its use in osteoporosis and/or bone loss) PI1100248. 2011

With A. A. Souto, L.A. Basso, M.M. Campos & N.F. Nicoletti. Formulação farmacêutica e processo para reduzir hepatotoxicidade (Pharmaceutical formulation and method for reducing hepatotoxicity) PI1001052-1 (2010) WO2011130817A1 (2011)

With L.A. Basso, E.L. Batista Jr. & J.M. Chies. Padrão de referência contendo sequencia nucleotídica, processo para detecção e/ou quantificaçãode sequências nucletídicas e Kit (Nucleotide sequence reference standard, process for detection and/or quantitation of nucleotide sequences and kit) PI0701529-1(2007)

With L.A. Basso, E.L. Batista Jr. & J.M. Chies. Synthesis of Standards for detection and quantification of nucleic acids and kit. PI0701529-1(2007) WO2008122097-A1 (2007)

With L.A. Basso, J.M. Chies, G. Renard, I.O. da Fonseca. Método de obtenção de sequências nucletídicas quiméricas e sequencia nucleotídica quimérica (Method for obtainment of chimeric nucleotide sequences and chimeric nucleotide sequences)  PI0506047-8 (2005) & WO20070680 A3 (2007)

With I.S. Moreira & L.A. Basso. Aplicação de Complexos de Metais de Transição para o tratamento de Tuberculose (Transition metal complex application for treatment of tuberculosis, complexes thereof and preparation thereof) PI0300770-7 (2003)