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Maximiliano Ruiz Castañeda

Maximiliano Ruiz Castañeda, Mexican biomedical scientist (Acambay, Mexico State 05 December 1896 – Ciudad de Mexico 01 October 1992)
 

With H. Zinsser & H. Mooser identified murine typhus (Rickettsia typhi) in 1930
 

METHODS/TECHNIQUES


Proposed the differential stain for the detection of rickettsiae and chlamydial elementary bodies in tissue samples (1930) 


With H. Zinsser. Method of obtaining large amounts of Rickettsia prowazeki by x-ray radiation of rats (1932)
 
Perfected a vaccine for exanthematic typhus known as Castañeda vaccine (1938)
 

Developed Ruiz Castañeda medium

With R. Tovar & R. Velez. Studies on brucellosis in Mexico. Comparative study of various diagnostic tests and classification of the isolate bacteria. J. Infect. Dis. 70:97-102, 1942
 

Developed bivalent vaccine for typhus (1944)

 
A serum agglutination technique in slides (1945)
 
Developed Castañeda rapid slide agglutination test for brucellosis 
A practical method for routine blood culture in brucellosis. Proc. Soc. Exper. Biol. Med. 64:114-5, 1947
 

Developed surface fixation method, forerunner of immunoblot

Surface fixation. A new method of detecting certain immunological reactions. Exp. Biol. Med. 73(1):46-9, 1950
 
Improved apparatus for the isolation of Brucella and Salmonella by hemoculture. Bull. World Health Organ. 14(4):795-6, 1956
 
With M.A. de los Corvera & J. Olarte. A new medium for the isolation of Brucella and Salmonella by blood culture. Bull. World Health Organ. 14(4):797, 1956
 
Rapid method for investigating the concentration of urea in the blood. Rev. Med. Hosp. Gen. 28(5): 369-71, 1965
 
Simplification of methods for the study of beta hemolytic Streptococcus in faryngeal exudates. Bol. Med. Hosp. Infant. Mex. 33(2):481-5, 1976
 
With Y. Naranjo. Rapid test for diagnosis of syphilis by means of the surface fixation method using as antigens VDRL and Treponema pallidum (strain Nichols). Arch. Invest. Mex. 9(4):559-64, 1978  
 
A simple test for detection of specific and unspecific immunological reactions in cancer. Arch. Invest. Mex. 11(1):83-93, 1980 
 
With A. Lopez Merino & F. Ruiz-Reyes. Rapid test for the diagnosis of onchocercosis. Bol. Med. Hosp. Inf. Mexico 39(4):265-7, 1982 
 
Discovered an autovaccine procedure for allergies
 

 HONORS 

Honorary Fellow, American Society of Immunology (1944)

Visiting Professor, Tulane University (1945-6)

Fellow, New York Academy of Sciences (1955)

Medicine & Physiology Nobel Prize nominee (1965)

 
 

EPONYMY 

Castañeda bottle for culture of Brucella

Ruiz Castañeda biphasic blood culture

Zinsser-Ruiz Castañeda method

Ruiz Castañeda reaction for typhoid (similar to Huddleson reaction)

Ruiz Castañeda reaction for brucellosis

Ruiz Castañeda staining for Rickettsiae (1930)