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Mauricio Rocha e Silva

Maurício Oscar da Rocha e Silva, Brazilian pharmacologist (Rio de Janeiro 19 September 1910 –São Paulo 19 December 1983)
 
Authored about 300 papers and 7 books
 
Co-authored with J. Garcia Leme & H. Rothschild Chemical Mediators of the acute inflammatory reaction edited by Pergamon Press in 1972 and worldwide used

With O.G. Bier noticed that the hemolysis is inhibited by hypertonic concentrations of NaCl (1935)
 
First stated the proteolytic theory of histamine release (1938)

Proved the heparin liberation in distinct types of shock

With S.O. Andrade & L.B. Teixeira. Coagulation defect in the shocks produced by trypsin peptone and ascaris extracts. Exp. Med. Surg. 4:260, 1946

With E.A. Scroggie, E. Fidlar & L.B. Jaques. Liberation of histamine and heparin by peptone from isolated dog’s liver. Proc. Soc. Exp. Biol. Med. 64:141, 1947

 

Discovered bradykinin

With W.T. Beraldo. Um novo principio autofarmacológico (bradicinina) liberado sob a ação de veneno de cobras e de tripsina. Ciência e Cult. 1:32-5, 1949

With G. Rosenfeld & W.T. Beraldo. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiol. 156:261-73, 1949
 
With Sylvia O. Andrade purified bradykinin (1956)
 
Clarified the etiology of a photosensitizing disease of cattle caused by plant named alecrim (Holocalyx glaziovii)
 
With A.M. Rothschild & I. Vugman established the role of cellular energetic metabolism in histamine release 
 
 

METHODS/TECHNIQUES

Method of assay of bradykinin upon the guinea pig gut. Acta Physiol. Lat. Am. 2(4):238-50, 1952
 

Developed an assay using Latin square design for histamine releasing action of anaphylatoxin

With A.M. Rothschild. Experimental design for bioassay of a material inducing strong tachyphylactic effect (anaphylatoxin). Br. J. Pharmacol. Chemother. 11(3):252-62, 1956 
 

Concerning the theory of receptors in pharmacology. A rational method of estimation of p Aτ. Arch. Int. Pharmacodyn. 118:74, 1959

 
With A. Antonio described perfusion method of rat paw subcutaneous tissue in Med. Exp. 3:371, 1960 

Proposed an indirect method for calculating pAx based on the ratios between the slopes of reciprocal dose-effect regressions obtained in presence and absence of the antagonist

 

With C.R. Diniz, I. F. de Carvalho & J. Ryan. A micromethod for the determination of bradykininogen in blood plasma. Nature 192:1194-5, 1961 
 

Developed a technique for detecting histamine in nano-quantities

With I. Vugman. Biological determination of histamine in living tissues and body fluids. In: Rocha e Silva, M. (editor). Handbook of experimental pharmacology, vol 18(1), 1966
 
With H. O. Schild developed the isolated diaphragm of guinea pig technique

Modified M. Rose device for myxomicetes rheotropism 

With A. Dreyfus. Sobre certos aspectos do hygrotropismo das larvas de Megaselia scalaris Loew. Rev. Biol. Hyg. 6(1):36-8, 1935

 
 

HONORS

Medicine & Physiology Nobel Prize nominee