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Luis Alberto Quesada Allue

Luis Alberto Quesada Allué, Argentine insect biochemist (Bordeaux, France 23 November 1942 -

Authored over 120 papers being most of them published in first-level journals

Described the chitin synthesis in insects

With L.R. Marechal & E. Belocopitow. Chitin synthesis in Triatoma infestans and other insects. Acta Physiol. Latinoam. 26(5):349-63, 1976

Found polyprenol-phosphates sugars in insects and studied its biosynthesis

With L.R. Marechal & E. Belocopitow. Biosynthesis of polyprenol phosphate sugars by Ceratitis capitata extracts. FEBS Lett. 67(3):243-7, 1976

Presented the first evidence of a protein glycosylation in a pluricellular invertebrate through dolichyl derivatives in Mol. Cell. Biochem. 33(3):149-55, 1980

Performed the first studies about glycoproteins in Trypanosoma cruzi

With J.J. Cazzulo & A.J. Parodi. The biosynthesis of mannose-containing glycoconjugates in the trypanosomatid Crithidia fasciculata. J. Protozool. 29(2):329, 1982

With A.J. Parodi. Protein glycosylation in Trypanosoma cruzi. I. Characterization of dolichol-bound monosaccharides and oligosaccharides synthesized “in vivo”. J. Biol. Chem. 257(13):7637-40, 1982

With A.J. Parodi. Novel mannose carrier in the trypanosomatid Crithidia fasciculata behaving as a short α-saturated polypreyl phosphate. Biochem. J. 212(1):123-8, 1983

Described in detail the transition from larval to pharate adult stages

With A. Rabossi & P. Wappner. Larva to pharate adult transformation in the medfly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). Can. Entomol. 124(6):1139–47, 1992

With A. Rabossi. Medfly eye pigments as markers of differentiation. Anales Asoc. Quim. Argentina 81:325, 1993

Performed the first analysis in vivo of synthesis and deposition of a glycoprotein

With G.L. Boccaccio. Synthesis and deposition of PCG-100, the main pupal cuticle glycoprotein of the medfly Ceratitis capitata. Arch Insect Biochem. Physiol. 27(3):217-34, 1994

Proposed an alternative model explaining the mechanism of water loss during sclerotization

With P. Wappner. Water loss during cuticle sclerotization in the medfly Ceratitis capitata is independent of catecholamines. J. Insect Physiol. 42(17):705-9, 1996

Demonstrated the onset of glycogen synthesis in insects

With D.S. Tolmasky & A. Rabossi. Synthesis and mobilization of glycogen during metamorphosis of the medfly Ceratitis capitata. Arch. Biochem. Biophys. 392(1):38-47, 2001

Discovered that enzyme NBAD-S plays a role in the immune system of insects and in the turnover of dopamine

With J. Schachter & M.M. Perez. The role of N-β-alanyldopamine synthase in the innate immune response of two insects. J. Insect Physiol. 53(11):1188-97, 2007

With M.M. Perez, J. Schachter & J. Berni. The enzyme NBAD synthase plays diverse roles during the life cycle of Drosophila melanogaster. J. Insect Physiol. 56(1):8-13, 2010

With L.M.Pujol-Lereis & A. Rabossi. Lipid profiles as indicators of functional senescence in the medfly. Exper. Geront. 47(6):465-72, 2012

First to demonstrate that after irradiation a fraction of tumor cells present large lipid bodies which mainly contain high concentration of triglycerides

With G.A. Pizzurro, F.P. Madorsky Rowdo, I.M. Pujol-Lereis, A.M. Copati, M.P. Roberti, J.L, Teillaud, E.M. Levy, M.M. Barrio & J. Mordoh. High lipid content of irradiated human melanoma cells does not affect cytokine-maturated dendritic cell function. Cancer Immunol. Immunother. 62(1):3-15, 2013

First to identify extracellular brownish spots in insects

With M.M. Perez, P.A. Bochichio & A. Rabossi Extracellular activity of NBAD-synthase is responsible for colouration of brown spots in Ceratitis capitata wings. J. Insect Physiol. 107:224-32, 2018

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