His son, Armando José Antonio Parodi Lailame, biochemist (Buenos Aires 16 March 1942 -

Showed that the dolichol P-dependent pathway of protein N-glycosylation was present in mammalian and yeast (1975-8)

First description of the role of dolichol derivatives in the initial stages of protein N-glycosylation

Unravelled a basic metabolic pathway leading to the formation of glycoproteins and polysaccharides in mammals, plants fungi and protozoa (1981-3)

Showed that in members of the Trypanosomatidae family the pathway of N-linked oligosaccharide processing of protein is similar found that found in other eukaryotic cells

With L.A. Quesada Allué & J.J. Cazzulo. Pathway of the protein glycosilation in the trypanosomatid Crithidia fasciculata. Proc. Nat. Acad. Sci. 78:6021-5, 1981

Established its occurrence in the endoplasmic reticulum (1984)

Suggested the role of transient glycosylation in quality control og glycoprotein folding (2004-5)

RELEVANT PAPERS

With O.A. Castro & F. Movsichoff. Preferential transfer of the complete glycan is determined by the oligosaccharyltransferase complex and not by the catalytic subunit. Proceed. Nat. Acad. Sciences USA 103:14756-60, 2006

With N. Keith & J.J. Caramelo. Glycoprotein tertiary and quaternary structures are monitored by the same quality control mechanism. J. Biol. Chem. 280:18138-41, 2005

With J.J. Caramelo, O.A. Castro & G. Prat-Gay. The endoplasmic reticulum glucosyltransferase recognizes nerly native glycoprotein folding internmediates. J. Biol. Chem. 279:46280-5, 2004

With J.E. Ugalde & R.A. Ugalde. De novo synthesis of bacterial glycogen: Agrobacterium tumefaciens glycogen synthase is involved in glucan initiation and elongation. Proceed. Nat. Acad. Sciences USA 100:10659-63, 2003

With J.J. Caramelo, O.A. Castro, L.G. Alonso & G. Prat-Gay. UDP-Glc: glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten-globule like folding intermediates. Proceed. Nat. Acad. Sciences USA 100:86-91, 2003

With C. Zuber, J.Y. Fan, B. Guhl, J.H. Fessler, C. Parker & J. Roth. Immunolocalization of UDP-Glc: glucoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality control. Proceed. Nat. Acad. Sciences USA 98:10710-5, 2001

With D.C. Tessier, D. Dignard, A. Zanpun, A. Radominska-Pandya, J.J.M. Bergeron & D.Y. Thomas. Cloning and characterization of mammalian UDP-glucose Glycoprotein Glycosyltransferase and the development of a specific substrate for the enzyme. Glycobiology 10:403-12, 2000

With M. Sousa. The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc: glycoprotein Glucosyltransferase. EMBO J. 14:4196-203, 1995

With V. Alvarez & R. Couso. Characterization of the mannose 6-phosphate dependent pathway of lysosomal enzyme routing in an invertebrate. Biochem. J. 310:589-95, 1995

With S. Merello & R.O. Couso. Characterization and partial purification of a novel enzymatic activity: UDP-GlcNAc Ser-protein N-acetylglucosamine-1-phosphotransferase from the cellular slime mold Dictyostelium discoideum. J. Biol. Chem. 270:7281-7, 1995

With S. Merello & M.T. Xavier. Novel Rhamnosyl and Ribosyl and uncommon (xylosyl) monosaccharide residues are present in asparagine-linked oligosaccharides of the trypanosomatid Blastocrithidia culicis. J. Biol. Chem. 269:20294-8, 1994

With S. Trombetta & M. Bosch. Glucosylation of glycoproteins by mammalian, plant, fungal and trypanosomatid protozoa microsomal membranes. Biochemistry 28:8108-16, 1989

With G.Z. Lederkremer. 3-0 methylation of mannose residues: a novel reaction in the processing of N-linked oligosaccharides occurring in Mucor rouxii. J. Biol. Chem. 259:12514-8, 1984

With D.H. Mendelzon & G.Z. Lederkremer. Transient glycosylation of protein-bound Man9GlcNAc2, Man8GlcNAc2 and Man7GlcNAc2 in calf thyroid cells: a possible recognition signal in the processing of glycoproteins. J. Biol. Chem. 258:8260-5, 1983

With L. Quesada Allué. Novel mannose carrier in the Trypanosomatid Crithidia fasciculata behaving as a short-saturated polyprenyl phosphate. Biochem. J. 212:123-8, 1983

With N.H. Behrens, L.F. Leloir & H. Carminatti. The role of polyprenyl-bound saccharides as intermediates in glycoprotein synthesis in liver. Proceed. Nat. Acad. Sciences USA 69:3268-72, 1972

With N.H. Behrens & L.F. Leloir. Glucose transfer from dolichol monophosphate glucose. The product formed with endogenous microsomal acceptor. Proceed. Nat. Acad. Sciences USA 68:2857-60, 1971

HONOURS

International Research Scholar, Howard Hughes Medical Institute (1997-2011)

Karl Meyer Award in Glycobiology, American Society for Glycobiology (2011)