José Pellegrino, Brazilian parasitologist and tropical physician (Passagem de Minas, Minas Gerais State 11 November 1922 - Belo Horizonte 10 February 1977)

From Italian parents

Authored over 350 papers

Described two Diptera species, Lutzomyia ferreirana and L. firmatoi with Barretto & Martins (1956)  

First report about Chagas disease transmission by blood transfusion

Transmissão da doença de Chagas pela transfusão sanguínea. Primeiras comprovações sorológicas de esquizotripanos em doadores e em candidatos a doadores de sangue. Rev. Bras. Med. 6(5):297-301, 1949

 

Identified 14, 15-epoxi-geranylgeraniol, from fruits oil of Pterodon pubescens which prevents the penetration of cercariae of Schistosoma into the skin of host

With M.F. Santos Filho, H.J. Monteiro, B. Gilbert & W.B. Mors. Chemoprophylactic agent in schistosomiasis: 14,15-epoxigeranylgeraniol. Science 157:950-1, 1967.

Standardized immunological reactions establishing its value in schistosomiasis epidemiology

Técnica de reação intradérmica para diagnóstico da esquistossomose. Rev. Bras. Malariol. Doenças Trop. 9:105-21, 1957

Diagnóstico da esquistossomose pela reação intradérmica. Rev. Bras. Doen. Trop. 9:105, 1957

Developed Kagan-Pellegrino-Memoria technique for preparation of antigens for Schistosoma mansoni

With J. G. Kagan & J.M. P. Memória. Studies on the standardization of the intradermal test for the diagnosis of bilharziasis. Amer.J. Trop. Med. Hyg. 10:200-7, 1961

Developed a method for preparation of Schistosoma mansoni antigens employing modified Coca’s solution

With J.G. Kagan. Critical review of immunological methods for diagnosis of bilharziasis. Bull. World Health Organization 25:611, 1961

Established technical basis for Chagas disease prophylaxis employing residual action insecticides (i.e. Gammexane or BHC in 1948) independently from Abalos

With E. Dias. Alguns ensaios com o “Gammexane” no combate aos transmissores da doença de Chagas no Brasil. Brasil Médico 62:185-91, 1948.

Proposed an evolutive and morphological classification of Schistosoma mansoni eggs

With G. Gazzinelli & F.J. R. Pinto. Purification and characterization of proteolytic enzyme complex of cercarial extract. Comp. Biochem. Physic. 18(14):689-700, 1966

With B. Gilbert, N. Nunes da Rocha & R. Borojevic. Schistosoma mansoni in vitro transformation of cercarial into schistosomules. Parasitology 64:333, 1972  

Identified over 20 drugs with experimental activity on schistosomiasis

 

Proposed cellophane paper model for measuring the papulae intensity in schistosomiasis intradermoreaction

With D.G. Macedo. Novo critério de leitura da reação intradérmica na esquistossomose. Rev. Bras. Malar. 8(3):499-509, 1956

PHYTOCHEMISTRY & PARASITOLOGY

With W.B. Mors, P.M. Baker, T.C.B. Tomassini, B. Gilbert, N. Katz et al. A atividade anti-helmíntica dos óleos essenciais e de seus componentes químicos. Anais Acad. Bras. Ciencias 44:423-8, 1972 

With B. Gilbert & D. Santos Filho. Extract of Enterolobium timbouva Martius, 1837, a penetration stimulant for cercariae of Schistosoma mansoni. Rev. Bras. Pesq. Med. Biol. 4(4-5):315-6, 1971

With B. Gilbert, J.P. Souza, C.C. Fortes, D. Santos Filho, A.P. de Seabra & M. Kitagawa. Chemo prophylactic agents in schistosomiasis. I. Active and inactive terpenes. J. Parasitol. 56:397, 1970

With P.M. Baker, C.C. Fortes, E.G. Fortes, G. Gazzinelli, B. Gilbert, J.N.C. Lopes, T.C.B. Tomassini & W. Vichnewski. Chemoprophylactic agents in schistosomiasis, eremanthine, costunolide, alpha cyclo costunolide and bisabolol. J. Pharm. Pharmacol. 24:853-7, 1972

With B. Gilbert, J.P. de Souza, M. Fasao & A.P. de Seabra. Esquistossomose: proteção contra infecção por terpenóides. Anais Acad. Bras. Ciencias 42:397-400, 1970 (Suppl)

With A.V. Pinto, M.C.R. Pinto, B. Gilbert & R.M. Mello. Schistosomiasis mansoni: blockage of cercarial skin penetration by chemical agents: I. Naphthoquinones and derivatives. Trans. Royal Soc. Trop. Med. Hyg. 71:133-5, 1977

OTHER TECHNIQUES/METHODS

With L.H. Pereira, T.E. Valadares, R.T. Mello & P.M.Z. Coelho. A new approach for screening prophylactic agents in schistosomiasis. Rev. Inst. Med. Trop. S. Paulo 16:123-6, 1974

With F.J. Ramalho Pinto, G. Gazzinelli, R.E. Howells, T.A. Mota-Santos & E.A. Figueiredo. Schistosoma mansoni: defined system for stepwise transformation of cercariae to schistosomula in vitro. Exp. Parasitol. 36:360-72, 1974

With F.M. Coelho, G. Gazzinelli & L.H. Pereira. Standardization of the Fe59 incorporation method in Biomphalaria glabrata for use in study of the crowding effect. Rev. Inst. Med. Trop. 15(6):417-20, 1973 

With N. Katz & A. Chaves. Uma técnica simples para a realização do exame de fezes quantitativo na esquistossomose. Cien. Cult. 24(6):416, 1972

With N. Katz & A. Chaves. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev. Inst. Med. Trop. S. Paulo 14:397-402, 1972

With C.E. Borda. An improved thick-smear for quantitative diagnosis of Schistosoma mansoni infections. Rev. Inst. Med. Trop. S. Paulo 10:71-5, 1971

With J. Faria. The oogram method for the screening of drugs in schistosomiasis mansoni. Amer.J. Trop. Med. Hyg. 14:363-9, 1965

With C.A. Oliveira, J. Faria & A.S. Cunha. New approach to the screening of drugs in chemotherapy of Schistosoma mansoni in mice. Amer. J. Trop. Med. Hyg. 11:201-15, 1962

With A.F. Siqueira. Técnica de perfusão para colheita de Schistosoma mansoni em cobaios experimentalmente infestados. Rev. Bras. Malar. Doen Trop. 8:589-97, 1956  

With Rosa M.B. Nunes. Technique for obtaining dried cercariae of Schistosoma mansoni for the preparations of antigens. Rev. Bras. Malariol. Doen. Trop. 8:397-404, 1956

With Z. Brener. Method for isolating schistosome granulomas from mouse liver. J. Parasit. 42:564, 1956

With D.G. Macedo. A simplified method for the concentration of cercariae. J. Parasit. 41:329-30, 1955

Técnica para reação de precipitina no diagnóstico da doença de Chagas com sangue colhido na polpa digital. O Hospital 4:437-41, 1953

Métodos e critérios para a realização de inquéritos sobre doença de Chagas em crianças. J. Pediat. 17(5):224-8, 1952