Antonio Cechelli de Mattos Paiva, Brazilian biochemist (Mogi Mirim, São Paulo State 21 June 1929 – São Paulo 18 May 2006)

Authored about 150 papers

With his wife gained international recognition for their work on polypeptides syntheses

SYNTHESES OF PEPTIDES

With T.B. Paiva et al. New specific antagonists of angiotensin I and II (1973)

With T.B. Paiva & M.E. Miyamoto. An analogue peptide of pepsitensin (1973)

With T.B. Paiva & M.E. Miyamoto. Synthesis of a proposed pepsitensin. J. Med. Chem. 16(3):280, 1973

With M. Tominaga, J.M. Stewart & T.B. Paiva. New bradykinin potentiating peptides (1975)

With G. Goissis & V.L.A. Nouailhetas. Biologically active retroenantiomers of angiotensin peptides (1976)

With C.R. Nakaie, M.E.M. Oshiro & G. Goissis. New peptide analogues of angiotensin II (1977)

With E.B. Sabia, M. Tominaga & T.B. Paiva. New analogues of snake venom peptides (1978)

With C.R. Nakaie, E.G. Silva, E.M. Cilli, R. Marchetto, S. Schreier & T.B. Paiva. Synthesis and pharmacological properties of TOAC-labeled angiotensin and bradykinin analogs. Peptides 23(1):65-70, 2002

OTHER CONTRIBUTIONS

With T.B. Paiva & J.L. Prado demonstrated that angiotensin and pepsitensin were distinct substances 

Non-identity between pepsitensin and hypertension revealed by paper electrophoresis. Science 120:611, 1954

With T.B. Paiva. The importance of the N-terminal of angiotensin II for its pressor and oxytocic activities. Biochem. Pharmacol. 5:181, 1960

With V.L.A. Nouailhetas, M.E. Miyamoto, G.B. Mendes & T.B. Paiva. New specific angiotensin inhibitors. J. Med. Chem. 16(1):6-9, 1973

With L. Oliveira & G. Vriend. A common step for signal transduction in G protein-coupled receptors. J. Comput. Aided Mol. Des. 7:649-58, 1993

A novel enzyme with activity tonin-like from rat submandibular gland (1993)

With N.L. Miasiro. Specific endothelin receptor agonists and antagonists disclose two new Etb receptors in the guinea pig ileum. Abst. XII Intern. Congr. Pharmacology p.572, 1994 

With L. Oliveira & G. Vriend. A low resolution model for the interaction of G proteins with G-protein coupled receptors. Protein Engin. 12:1087-95, 1999

With M. Tominaga, S.R. Barbosa, S. Schreier, C.R. Nakaie et al. Fmoc-POAC: [(9-fluorenylmethyloxycarbonyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl-3-amino-4-carboxylic acid]: A novel protected spin labeled amino acid for peptide and protein chemistry. Chem. Pharm. Bulletin 49(8):1027-9, 2001 

With L. Oliveira, P.B. Paiva & G. Vriend. Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein. Proteins 52:553-60, 2003

BRAZILIAN PATENTS

With C.R. Nakaie, M. Tominaga, S.R. Barbosa, R. Marchetto & S. Schreier. Síntese de um novo derivado de aminoacido paramagnético (epm-5) para uso em marcação de diferentes macromoléculas e sistemas de interesse químico-biológico PI9903137-0 A2 (1999)

With J.B. Pesquero, J.L. Pesquero, R.C. Araújo, M.A.S. Mori & M.S. Bader. Mecanismos e drogas utilizados no tratamento de diabetes, obesidade e controle dos distúrbios da fome (2005)

HONOURS 

100 Best Scientists of the World, Banning Foundation, Cambridge, United Kingdom (2006)

His wife, Therezinha Bandiera de Paiva, pharmacologist (Paraguaçu Paulista, São Paulo State 20 April 1929 – São Paulo 15 March 2011)

From Italian descent  

See above 

BRAZILIAN PATENT

With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmacêutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em animais PI0400994-0 A2 (2004)

With E. Achar, A.H. Campos, W.S. Almeida, R.A.N. Achar & N. Schor. Uso da amitriptilina, composição, forma farmaceutica, produto alimentício e método para prevenção, tratamento e eliminação de cálculos renais em humanos PI0400995-9 A2 (2004)