Alejandro Constantino Paladini, Argentine biochemist (Buenos Aires 19 April 1919 – 15 September 2012) With L.F. Leloir identified and isolated 2 new
coenzymes (1948) With R. Caputto, C.E. Cardini and L.F. Leloir discovered sugar nucleotides, determined its
chemical nature and showed that play a key role in sugar interconversion and
polysaccharides synthesis (1948) Established the structure of antibiotic tyrocidine A
(1951-2) With J.M. Dellacha, J.A. Santomé & M.A. Enero
isolated and characterized ovine growth hormone (1970) With J. A. Santomé & J.M. Dellacha elucidated
amino acid sequence and the structure of bovine growth hormone (1973) With R.D. Conde, J.A. Santomé & J.M. Dellacha
isolated, characterized and purified equine growth hormone (1973) With Pena, Medina, Novas & De Robertis
discovered N-butyl-β-carboline-3-carboxylate that binds to cerebral
benzodiazepine receptors (1986) With J.H. Medina, H. Viola & C. Wolfman
proposed flavonoids as a new family of benzodiazepine receptor ligands (1997) METHODS/TECHNIQUES With Morris developed a method for
determination of angiotensin in blood With E. Braun-Menendez & O.A. Scornik.
Further improvements on a method for the estimation of angiotensin in blood.
Acta Physiol. Lat. Am. 10:64-7, 1960 With N. Gonzalez Cadavid. Automatic amino acid
analysis: reagent and instrumental improvements. Anal. Biochem. 9:170-4,
1964 Eponym of Paladini-Leloir solvent PATENTS With B.K. Cassels, F.J. Dajas, J.H. Medina & R.H.
Silveira. Flavonoid and biflavonoid derivatives, their pharmaceutical
compositions, their anxiolytic activity
US5756538 (1998) & US 6004998 (1999) With J.H. Medina. Use of nitroflavonoids for the treatment of anxiety. US6080780 (2000) |
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