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Ivan Mota Albuquerque

Ivan da Mota e Albuquerque, Brazilian immunologist (Recife 09 October 1920 – São Paulo 25 September 2014)

Authored at least 132 papers
 
ACHIEVEMENTS

Demonstrated that granulations of mast cells store histamine 

With L.C.U. Junqueira, W.T. Beraldo & R.G. Ferri. Intracellular distribution of histamine. Nature 174:698-9, 1954


Discovered IgE antibodies before Ishizaka
 
Demonstrated mast cells role in anaphylaxis and other IgE-dependent phenomena

First to identify the biological activity and properties of IgE and IgG1 antibodies
 

Described antigen-induced mast cell degranulation in vitro (1956) and in vivo

With I. Vugman. Effect of anaphylactic shock and compound 48-80 on the mast cells of the guinea-pig lung. Nature 177:427-9, 1956
 

Concluded that mast cells have antibodies fixed on them

With W. Dias da Silva. Antigen-induced damage to isolated sensitized cells. Nature 186:245-6, 1960 

With W. Dias da Silva demonstrated that in low concentration of anti-histamine substances inhibit their release by mast cells and in high concentration occur the inverse (1960)


With W. Dias da Silva showed that anaphylactic antibodies perform reactions only after binding to surface receptors on mast cells


Suggested the existence of mast cell sensitizing antibody (1961)


Characterized the mast cell sensitizing antibody

Biological characterization of mast cell sensitizing antibodies. Life sciences 1:465-74, 1963 
 
First obtained the induction of an antibody able to sensitize  mast cells (1963)  
 
Obtained a new rattle snake antivenin serum (1999)

With L.C.U. Junqueira, W.T. Beraldo & A.G. Ferri. Action of peptone on mastcells of the dog. Nature 173:547, 1954
 
With O. Bier, W. Dias da Silva  & N. Vaz, authored Imunologia Básica e Aplicada (Fundamentals of  Immunology), translated to English and German (1973) 
 
 
METHODS
A method for quantitative estimation of mast cells in the bone marrow of the rat. Blood 6:81, 1951
 

Developed Braga-Mota method  

With F. Braga. Homologous passive cutaneous anaphylaxis (PCA) in mice and heterologous PCA induced in rats with mouse IgE. Immunol. 30:655-57, 1976
 
With I. Fernandes, F. Gourmont, D. Latinne et al. A rapid and efficient purification method for horse IgG(T) using a rat monoclonal antibody. Braz. J. Med. Biol. Research 27:2599-06, 1994

HONOURS

Visiting Professor, Department of Medicine, School of Medicine, Georgetown University, United States 

Honorary Research Assistant, University College of London (1957-8)