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Cesar Milstein

Cesar Milstein, British / Argentine (Bahía Blanca, Buenos Aires Province 08 October 1927- Cambridge, england 24 March 2002)

From Ukrainian and Lithuanian Jewish descent
 
ACHIEVEMENTS
Authored 314 papers 
 
Studied the structure of antibody proteins and the genetic study of antibody diversification
 
A simple test for the presence of metals in biological materials. Nature 185:386-7, 1960 
 
Defined the inter-heavy chain disulfide bridges that characterize each immunoglobulin class
 
One of first to determinate the complete sequence of immunoglobulin light chain  
 
With George Brownlee discovered the junction between variable and constant regions of immunoglobulin  (1972)
 
Demonstrated the importance of somatic hypermutation of immunoglobulin V genes in antibody affinity maturation 
 

Developed the hybridoma technique for the production of monoclonal antibodies

With Georges J. F. Kohler. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-7, 1975 
 

HONORS

Medicine & Physiology Nobel Prize 1984

Wolf Prize in Medicine 1980

Louisa Gross Horwitz Prize 1980

Asteroid Milstein 11776