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Fuad Lechín

Fuad Lechín Corban, Venezuelan neuropharmacologist (08 August 1928 –

 From Lebanese parents


Authored over 240 papers and 4 books


Developed a new treatment of bronchial asthma and myasthenia gravis

Demonstrated that drugs which enhances uptake by presynaptic serotonergic axons are potent anti-narcoleptic agents in patients resistant to methyl phenidate 

First to demonstrate the antidiarrheal effect of clonidine, dihydroergotamine, and other alpha adrenergic antagonists, as well as dopaminergic blocking agents

Enunciated the adrenergic theory of schizophrenia


FOUND

That patients affected by vertigo have raised levels of free serotonin in plasma

Two types of neurochemical disorders underlying hyperkinetic children (excessive free serotonin in plasma and excessive dopaminergic activity with noradrenergic over activity)

That patients displaying post-traumatic stress disorder show total exhaustion of central noradrenergic, dopaminergic and serotonergic activity

That symptomatic asthma patients show increased plasma serotonin values 


OTHERS

With B. Van der Dijs & A.E. Lechin. Tianeptine. A new exploratory therapy for asthma. Chest J. 125(1):348-9, 2004

With B. Van der Dijs. Physiological, clinical and therapeutic basis of a new hypothesis for headache. Headache 20(2):77-84, 1980

With B. Van der Dijs, E. Lechin, F. Peña & A. Bentolilla. The dopaminergic and noradrenergic blockades: a new treatment for headache. Headache 18(2):69-84, 1978

New method of investigation of exocrine secretion of the pancreas: preliminary communication. Gac. Med. Caracas 61(3-5):89-110, 1954

Un nuevo modelo de dilatador esofágico. Gen 7:1-2, 1952-3


Papers in top-journals

With B. Van der Dijs & A.E. Lechin. Tianeptine, plasma serotonin and pulmonary hypertension. Lancet 361(9351):87, 2003

Intestinal hormones and plasma insulin. Lancet 2:35-6, 1966

With B. Van der Dijs. Glucose disposal. Lancet 2:1122, 1964  


HONOURS

Medicine and Physiology Nobel Prize nominee (2001)

2000 Outstanding Scientists of the 20th Century, International Biographic Centre (2000)

500 Leaders of Influence, American Biographical Institute (2000)


LINKS

www.lechin.com