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Yedy Israel

Yedy Israel Jacard, Chilean biochemist (Temuco 19 September 1939 –

Recognized as an international reference on gene therapy of alcoholism

Authored 208 papers, 34 book chapters and 12 books with 12,000 citations and 62H-index


With M.E. Quintanilla, L. Tampier, E. Karahanian, M. Rivera-Meza & M. Herrera Marschitz. Reward and relapse: complete gene-induced dissociation in an animal model of alcoholic dependence. Alcohol Clin. Exp. Res. 36:517-22, 2012 

With P. Ocaranza, M.E. Quintanilla, L. Tampier, E. Karahanian & A. Sapag. Gene therapy reduces ethanol intake in an animal model of alcohol dependence. Clin. Exp. Res. 32:52-7, 2008

With M.E. Quintanilla, l. Tampier, A. Sapag & Z. Gerdzen. Sex differences, alcohol dehydrogenase, acetaldehyde burst and aversion to ethanol in the rat: a systems perspective. Am. J. Physiol. Endocrinol. Metab. 293:E351-7, 2007 

With M.E. Quintanilla, A. Sapag & L. Tampier. The UChA and UChB rat lines; metabolic and genetic differences influencing ethanol intake. Addiction Bull. 11:310-23, 2006

With M.E. Quintanilla, L. Tampier & A. Sapag. Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Pharmacogenet. Genomics 15:427-31, 2005

With M.E. Quintanilla, L. Tampier, A. Valle Prieto & A. Sapag. Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats. FASEB J. 19:36-42, 2005

Covalent binding of acetaldehyde to liver tubulin: a step in the right direction. Hepatology 9:161-2, 1989

With H. Orrego & O. Niemela. Immune responses to alcohol metabolites: pathogenic and diagnostic implications. Sem. Liver Dis. 8:81-90, 1988

With F.J. Carmichael, V. Saldivia, J. McKaigney & H. Orrego. Ethanol-induced increase in portal hepatic blood flow: interference by anesthetic agents. Hepatol. (Baltimore) 7:89-94, 1987  

With E. Hurwitz, O. Niemela & R. Arnon. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc. Natl. Acad. Sci. USA 83:7923-7, 1986

With S. Holt & H.A.Skinner. Early identification of alcohol abuse: clinical and laboratory indicators. Can. Med. Assoc. J. 124:1279-95, 1981

With H. Orrego. Hepatocyte demand and substrate supply as factors in the susceptibility to alcoholic liver injury: pathogenesis and prevention. Clin. Gastroenter. 10:355-73, 1981

With J. Talesnik & S. Belo. Enhancement of noradrenaline-induced metabolic coronary dilation by ethanol. Eur. J. Pharmacol. 61:279, 1980

With J.M. Khanna. Ethanol metabolism. Int. Rev. Physiol. 21:275-15, 1980

With J.M. Khanna, H. Orrego, G. Rachamin, S. Wahid, R. Britton, A. MacDonald & H. Kalant. Studies on metabolic tolerance to alcohol, hepatomegaly and alcoholic liver disease. Drug Alcohol Depend. 4:109,-18, 1979

With L. Videla, V. Fernandes-Vilela & J. Bernstein. Effects of chronic ethanol treatment and thyroxine administration on ethanol metabolism and liver oxidative capacity. J. Pharmacol. Exp. Ther. 192:565, 1975

With L. Videla, K.W. Flattery & E.A. Sellers. Ethanol metabolism and liver oxidative capacity in cold acclimation. J. Pharmacol. Exp. Ther. 192:575, 1975

With H. Kalant, H. Orrego, J.M. Khanna, L. Videla & J.M. Phillips. Experimental alcohol-induced hepatic necrosis: suppression by propylthiouracil. Proc. Natl. Acad. Sci. USA 72:1137-41, 1975

With L. Videla & J. Bernstein. Liver hypermetabolic state after chronic ethanol consumption: hormonal interrelations and pathogenic implications. Fed. Proc. 34:2052-9, 1975

With H. Seiden & H. Kalant. Activation of ethanol metabolism by 2,4-dinitrophenol in the isolated perfused rat liver. Biochem. Pharmacol. 23:2334, 1974

With J. Bernstein & l. Videla. Metabolic alterations produced in the liver by chronic ethanol administration. II. Changes related to energetic parameters of the cell. Biochem. J. 134:515, 1973

With D.B. Goldstein. Effects of ethanol on mouse brain (Na+K+) activated adenosine triphosphate. Life Sci. 2(2):957-63, 1972

Cellular effects of alcohol. A review. Quart. J. Stud. Alcohol 31:293-316, 1970

With L. Videla. Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administration. Biochem. J. 118:275, 1970

With H. Kalant & M.A. Mahon. The effect of ethanol on acetylcholine synthesis, release and degradation in brain. Can. J. Physiol. Pharmacol. 45:172, 1967

With H. Kalant & A.E. LeBlanc. Effect of lower alcohols on potassium transport and microsomal adenosine triphosphatase activity of rat cerebral cortex. Biochem. J. 100:27-33, 1966

With H. Kalant. Effect of ethanol on electrolyte transport and electrogenesis in animal tissues. J. Cell. Comp. Physiol. 65:127, 1965

With H. Kalant. Effect of ethanol on the transport of sodium in the frog skin. Nature 200:476, 1963

PATENTS (6 patents for treatment of alcoholism-related products) 

With M.E. Quintanilla Gonzalez, L. Tampier De Jong, A.D. Bustamante Cadiz, M. Herrera Marschitz & E. Karahanian Vartevanian. Expression vectors which inhibit synthesis of catalase and uses thereof  (20120107923) 


Jellinek Memorial Award in Alcoholism, Jellinek International Foundation (1980)

Distinguished Researcher Award, US Research Society on Alcoholism (1990)

Thurman Lectureship Award, Bowes Center for Alcohol Studies, University of, North Carolina (2006)

Ishii Memorial Award, International Society for Biomedical Research on Alcoholism (2014)

Lieber Lectureship Award, European Society for Biomedical Research on Alcoholism (2017)