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Pedro Gaspar Guertzenstein

Pedro Gaspar Guertzenstein, Jewish Brazilian cardiovascular physiologist (São Paulo 06 January 1938 – São Paulo 17 July 1994)



Established the foundation of current view of the ventrolateral medullary vasomotor nuclei and their role in the arterial blood pressure (1971-4)


Established the ventral surface of the bulb as regulating region of sympathetic tonus

Blood pressure effects obtained by drugs applied to the ventral surface of the brain stem. J. Physiol. 229:395-408, 1973


Defined the rostroventrolateral medulla precise location of the most important source of tonic excitation to sympathetic neurons in the intermediolateral cell column of the spinal cord

With A. Silver. Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions. J. Physiol. 242:489-503, 1974


Described the caudal ventrolateral medulla

With W. Feldberg. Vasodepressor effect obtained by drugs acting on the ventral surface of the brain stem. J. Physiol. 258:337-55, 1976


Characterized the cardiovascular function of caudal ventrolateral medulla

With O.U. Lopes. A depressor area on the ventral surface of the medulla. J. Physiol. 301:35-6, 1980


Proposed the existence of caudal pressor area

With W. Feldberg. Blood pressure effects of leptazol applied to the ventral surface of the brain stem of cats. J. Physiol. 372:445-56, 1986


Showed that caudal pressor area contains cells with a tonic pressor activity that contributed to maintenance of baseline levels of arterial pressure and that caudal pressor area-induced cardiovascular responses were mediated by caudal ventrolateral medulla with the involvement of both glutamatergic and GABAergic synapses

With O.U. Lopes, R.R. Campos Jr., O.S. Possas & S.L. Cravo. The caudal pressor area: a new region of the ventrolateral medula involved in cardiovascular regulation. Lung Biol. Health Dis. 82:817-932, 1995


With J.E.C. Lacerda, G.C. Araújo, A.A. Santos & O.U. Lopes. Padronização de um método para canulação crônica da área rostroventrolateral em ratos. Anais FeSBE 10:118, 1995