Sérgio
Henrique Ferreira, Brazilian
pharmacologist (Franca, São Paulo State 04 October 1934 – Ribeirão Preto 17 July 2016) ACHIEVEMENTS Gained international recognition for
his studies on field of inflammatory analgesics Authored 281 papers (until early 2013) Proposed that the aspirin’s
mechanism of action was due to prevention of pain receptors
sensibilization as a consequence of
prostaglandin synthesis inhibition With J.R. Vane and Y.S. Bakhle
obtained experimental evidence that angiotensin inhibition could be a hypertension
therapy With M. Rocha e Silva discovered and
isolated bradykinin potentiating factor or BPF (1965) Discovered peripheral analgesic
mechanism of action of dipyrone Discovered peripheral action of
morphine and the phenomenon of tele-antagonism Observed hyperalgesia mechanism Characterized the phenomenon of retrograde
sensibilization of primary sensorial neuron that consists in glutamate release
in spinal cord of primary peripheral neuron Demonstrated cytokines involvement
in inflammatory pain Discovered anti-hypertensive
converting enzymes inhibitors Proposed the development of opiates
drugs of peripheral action Contributed significantly to define the role of inflammatory mediators to inducing hyperalgesia Proposed the idea that the development of inflammatory pain depends on hierarchical release of distinct mediators Proposed that the inflammatory pain followed stimuli action on prostaglandin-sensitized nociceptors (1972) Discovered that a distinct class of analgesics is able to counteract the ongoing sensitization of the primary sensory neuron via stimulation of the arginine/-nitric oxide pathway Described an antagonist of interleukin 1 that is being developed as a model for a new class of analgesics Found that interleukin I mediates the endogenous release of prostaglandins and interleukin 8 is responsible for the development of the sympathetic hyperalgesia Characterized
the retrograde sensitization of the primary sensory neuron (2008) HONORS Mahidol Award, Prince Mahidol Foundation (2008) Honorary Member, International Association for the Study of Pain (2005) Member, National Academy of Sciences (2002) Werle Commemorative Medal (1993) Ferreira Award, Norwegian Hypertension Society (1990) |
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