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Mohamed Hilmy Elnagdi

Mohamed Hilmy Ali Elnagdi, Egyptian organic chemist (Mansoura 01 September 1941 –

Authored 450 papers with over 6,400 citations 

Synthesized a variety of compounds related to pyrazoles, thiazoles and oxazoles

First to report the utility of arylidene malononitrile as precursor to heteroaromatics


With M.S. Moustafa, S.M. Al-Mousawi, N.M. Hilmy et al. Unexpected behavior of enaminones: interesting new routes to 1,6-naphthyridines, 2-oxopyrrolidines and pyrano[4,3,2-de]-[1,6]naphthyridines. Molecules 18(1):276-86, 2013

With S.M. Ashkar, M.A. El-Apasery, M.M. Touma et al. Synthesis of some novel biologically active disperse dyes derived from 4-methy1-2,6-dioxo-1- propy1-1,2,5,6-tetrahydropyridine-3-carbonitrile as coupling component and their colour assessment on polyester fabrics. Molecules 17(8): 8822-31, 2012

With O.S. Zaky, M.S. Moustafa, M.A. Maghraby et al. Scope and limitations of a novel synthesis of 3-arylazonicotinates. Molecules 17(5): 5924-34, 2012

With H.M. Al-Matar, A.Y. Adam, K.D. Khalil et al. Studies with 3-oxoalkanenitriles: novel rearrangements observed while exploring the utility of 2-cyanoacetyl-l-methylpyrrole as a precursor to pyrrole substituted heterocyclic compounds. Arkivoc 1-15, part 6, 2012

With H. Behbehani, H.M. Ibrahim, S. Makhseed et al. 2-aminothiophenes as building blocks in heterocyclic synthesis: synthesis and antimicrobial evaluation of a new class of pyrido[1,2-a]thieno[3,2-e]-pyrimidine, quinoline and pyridin-2-one derivatives. European Journal of Medicinal Chemistry. 52: 51-65, 2012

With H.M. Al-Matar, K.D. Khalil, M.F. Al-Kanderi et al. Studies on 3-oxoalkanenitriles: novel rearrangement reactions observed in studies of the chemistry of 3-heteroaroyl-3-oxoalkanenitriles as novel routes to 2-dialkylaminopyridines. Molecules 17(1):897-09, 2012

With N.A. Al-Jalal, M.R. Ibrahim, N.A. Al-Awadi et al. The photochemistry of benzotriazole derivatives. part 2: photolysis of 1-substituted benzotriazole arylhydrazones: new route to phenanthridin-6-y1-2-phenyldiazines. Molecules 16(12):10256-68, 2011

With S. Moustafa & S.M. A-Mousawi. Studies of functionally substituted enamines: a new step-one method for the formation of tetrahydroquinoline and nicotinonitrile derivatives. Synlett. 15:2237-41, 2011

With S.M. Al-Mousawi, M.S.Moustafa, I.A. Abdeihamid et al. Reassignment of the structures of condensation products of alpha-keto alpha'-formylarylhydrazones with ethyl cyanoacetate: a novel route to ethyl 5-arylazo-2-hydroxynicotinates. Tetrahedron Letters 52(2): 202-4, 2011

With S.M. Al-Mousawi & M.S. Moustafa. On the reaction of phenacylmalononitrile with hydrazines: a new route to pyrazolo[3,4-c]pyridazine, isoxazolo[5,4-clpyridazine and pyrimido[4,5-c]-pyridazine. Journal of Saudi Chemical Society 15(4):309-12, 2011 (Special issue)

With H.M. Ibrahim, H. Behbehani, S. Makhseed et al. Acylation of heteroaromatic amines: facile and efficient synthesis of a new class of 1,2,3-triazolo[4,5-13]pyridine and pyrazolo[4,3-b]pyridine derivatives. Molecules 16(5):3723-39, 2011

With F.M. A.A. El-Taweel. Studies with enaminones: synthesisof new coumarin-3-yl azoles, coumarin-3-yl azines, coumarin-3-yl azoloazines,coumarin-3-yl pyrone and coumarin-2-ylbenzo[b]furans. Journal of Heterocyclic Chemistry 38(4):981-4, 2001

With F. Alomran, N. Alawadi A. Abouelkhair et al. Synthesis of new aryl and heteroaromatic substituted pyridines, pyrazoles, pyrimidines and pyrazolo[3,4-d]pyridazines. Organic Preparations and Procedures International 29(3):285-92, 1997

With F. Alomran, M.M.A. Khalik, A. Abouelkhair et al. Studies with functionally substituted heteroaromatics: a novel route for the synthesis of 1-aryl-6-oxopyridazinones, 1-arylpyridazine-6-imines and 1 -aryl-6-imino-4-pyridazinals. Synthesis 1:91, 1997

With H.Alawadhi, F. Alomran et al. New synthetic approaches to condensed pyridazinones - alkylpyridazinyl carbonitriles as building-blocks for thesynthesis of condensed pyridazinones. Tetrahedron 51(46):12745-62, 1995

With A.W. Erian. Studies on alkyl-substituted, heteroaromatic carbonitriles -novel synthesis of thienoazines and benzoazines. Liebigs Annalen der Chemie 12: 1215-9, 1990

With A.M. Negm & A.W. Erian. Studies with alkylheteroaromatic pi-deficient compounds – novel synthesis of thieno[3,4-d]pyridazines and phthalazines. Liebigs Annalender Chemie 12: 1255-6, 1989

With A.G. A Elagamey, S.Z. Sawllim, F.M.A. Eltaweel et al. Nitriles in heterocyclic synthesis - novel syntheses of benzo[b]pyrans,naphtho[1 ,2-b]pyrans, naphtho[2,1-b]pyrans, pyrano[3,2-h]quinolines and pyrano[3,2-c]quinolines. Collection of Czechoslovak Chemical Communications 53(7):1534-8, 1988

With E.A.A. Hafez, A.G.A. Elagamey et al. Nitriles in heterocyclic synthesis - novel synthesis of benzo[c]-coumarin and of benzo[c] pyrano[3,2-c]quinoline derivatives. Heterocycles 26(4):903-7, 1987

With R.M. Abdelmotaleb, M. Mustafa et al. Studies on heterocyclic enamines - new syntheses of h-4-pyranes, pyranopyrazoles and pyranopyrimidines. Journal of Heterocyclic Chemistry 24(6):1677-81, 1987

With G.E.H. Elgemeie, M.M.M. Sallam, S.M. Sherif et al. A novel synthesis of 4-h-thiopyrans – unexpected products of reaction of cyanothioacetam ide with cinnamon itrile derivatives. Heterocycles 23(12): 3107-10, 1985

With H.A. Elfahham, F.M. Abdelgalil, Y.R. Ibraheim et al. Activated nitriles in heterocyclic synthesis – a novel synthesis of pyrazolo[1,5-a]pyrimidines and pyrano[2,3-c]pyrazoles. Journal of Heterocyclic Chemistry 20(3): 667-70, 1983

With H.A. Elfahham, S.A.S. Ghozlan et al. Activated nitriles in heterocyclic synthesis – a new procedure for the synthesis of pyrimidine-derivatives. Journal of the Chemical Society - Perkin Transactions 1(11):2667-70, 1982

With S.M. Fahmy, N.M. Abed, R.M. Mohareb et al. Activated nitriles in heterocyclic synthesis - novel synthesis of pyridazines, pyridines, andisoxazoles. Synthesis 6: 490-3, 1982

With H.A.F. Daboun, S.E. Abdou, M.M. Hussein et al. Activated nitriles in heterocyclic synthesis - novel syntheses of pyrrolo[1,2-c]imidazole and pyrano[2,3-d]imidazole derivatives. Synthesis 6: 502-4, 1982

With M.R. H. Elmoghayar, M.K.A. Ibraheim, A.H.H. Elghandour et al. A novel synthesis of thiazolo[2,3-alpha]pyridine derivatives. Synthesis 8: 635-7, 1981

With S. Abdou, S.M. Fahmy. K.U. Sadek et al.  Activated nitriles in heterocyclic synthesis – a novel synthesis of pyran o[2,3-c]pyrazoles. Heterocycles 16(12): 2177-80, 1981

With M. Riffaat. H. Elmoghayar et al. Reaction of malononitrile with thioglycolic acid – novel procedure for the synthesis of thiazolone derivatives. Journal of Heterocyclic Chemistry 16(8):1541-3, 1979

With S.M. Fahmy, E.A.A. Hafez et al. Pyrimidine-derivatives and related com pounds – novel synthesis of pyrimidines, pyrazolo[4,3-d]pyrimidines and isoxazolo[4,3-d]pyrimidine. Journal of Heterocyclic Chemistry 16 (6):109-11, 1979

With M.R.H. Elmoghayar, E.M. Kandeel et al. Reactions with heterocyclic diazonium salts - new routes for synthesis of pyrazolo[1,5-c]-1 ,2,4-triazoles and pyrazolo[1 ,5-c]-as-triazines. Journal of Heterocyclic Chemistry 14(2):227-30, 1977

With E.M. Kandeel, E.M. Zayed et al. Pyrimidine-derivatives and related compounds. 6. Novel synthesis of 3,5-diacetam idopyrazole and of 2-aminopyrazolo[1,5-a]pyrim idines. Journal of Heterocyclic Chemistry 14(1):155-7, 1977

With D.H. Fleita & M.R. Elmoghayar. Reactions with beta-cyanoethylhydrazine .2. Synthesis of some 4,5,6,7-tetrahydropyrazolo[1 ,5-a]pyrimidine derivatives. Tetrahedron  31(1): 63-7, 1975