Clemente Estable Fallabella, Uruguayan
histopathologist and neurophysiologist (Santa Lucia, Canelones Department 1894
– Montevideo 27 October 1976) Son of Italian immigrants Authored about 150 works ACHIEVEMENTS
Enunciated concepts on comparative structure in brain cortex Note sur la structure comparative de
l’ecorce cerebelleuse et derives physiologiques possibles. Trav. Lab. Rech.
Biol. Univ. Madrid 21:169-256, 1923 Enunciated the concept of hipocytomorphosis Hipocitomorfosis. Arch. Soc. Biol.
Montevideo 1:361-74, Formulated the concept of reversibility synapses and morphological quantitative concepts as synaptic valence and synaptic spectrum Espectro
sináptico, constantes sinápticas y revisión del concepto de sinapsis. Reunión
Cient. Asoc. Latinoam. Cien. Fisiol. Punta del Este 75-76, 1957 Described nucleolonema, a new cell structure With
Roberto J. Sotelo. Una nueva estructura celular: el nucleolonema. Rev. Fac. Hum. Cien. Montevideo 7:47-68, Created the concept of synaptic pathology Pathology of the interneuronal
synapses. Excerpta Med. Intern. Congress Series 100:463-8, 1965 Discovered and described the trophic
function of synapse (1956-8) First to describe axo-axonic synapse
Demonstrated that Purkinje cells axons of cerebellum extend to nuclei of encephalic axis and spinal cord (1927) Described accurately the
morphological neuronal changes that characterize many neurodegenerative
diseases Showed how drugs modify the
interneuronal connections With chemist L.F. Fieser purified
and synthesized gonyleptin from opilion Gonyleptus
sp. (1955) METHODS Created endocardiac biomicroscopy With
Alberto Vaz Ferreira. Methode pour l’examen microscopique “in vivo” du coeur dês vertébrés. Comp. Rend. Soc. Biol. Paris 106:847-50, 1931 Created bioiridomicroscopy LINKS http://www.smu.org.uy/dpmc/hmed/historia/articulos/estable.pdf http://www.revistacts.net/files/rodriguez_ithurralde_editado.pdfHis nephew, José Jesus Estable Parodi, physiologist and pharmacologist (Montevideo 22 September 1905 – 10 December 1976) Authored 66 papers DESCRIBED TECHNIQUES With H.J. Rossello. Nueva tecnica de descerebración en el perro. Comptes Rendus des Sciences de la Société de Biologie et ses filiales et associens CXI (32):406, 1932 With C. Bordoni Posse & E.C. Palma. La tecnica de arteriografia de contraste y sus resultados. Rev. Inform. Terap. 19:106, 1937 PAPERS WITH FOREIGN AND FAMOUS SCIENTISTS T.H. Sollmann Action of procaine, salicylate and benzoate of sodium on the excitability of skeletal muscle and of nerve. Anesth. 9(2):194-9, 1948 Survival time of refrigerated mammalian muscle and nerve after somatic death. Am. J. Physiol. 156(3):328, 1949 With S.O. Hoerr. Loss of excitability of frog sciatic nerve and skeletal muscle on deep-freezing. Am. J. Physiol. 156(3):333, 1949 C. Heymans On new nicotinolytic compounds. Science 109 (2823):122, 1949 With S. Castillo de Bonneveaux. Sur la pharmacologie de la phénothiazinyl-ethyldiéthylamine (2987 R.P.). Arch. Intern. Pharmacodyn. Therapie LXXIX (2-3):123, 1949 With S. Castillo de Bonneveaux. Nicotinolytic action of diethylaminoethylphenothiazine (2987 R.P. or Diparcol). Arch. Intern. Pharmacodyn. Therapie LXXIX (2-3):185, 1949
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