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Clemente Estable

Clemente Estable Fallabella, Uruguayan histopathologist and neurophysiologist (Santa Lucia, Canelones Department 1894 – Montevideo 27 October 1976)
Son of Italian immigrants
 
 
Authored about 150 works
 
 
ACHIEVEMENTS

Enunciated concepts on comparative structure in brain cortex

Note sur la structure comparative de l’ecorce cerebelleuse et derives physiologiques possibles. Trav. Lab. Rech. Biol. Univ. Madrid 21:169-256, 1923 
 

Enunciated the concept of hipocytomorphosis

Hipocitomorfosis. Arch. Soc. Biol. Montevideo 1:361-74,
 

Formulated the concept of reversibility synapses and morphological quantitative concepts as synaptic valence and synaptic spectrum

Espectro sináptico, constantes sinápticas y revisión del concepto de sinapsis. Reunión Cient. Asoc. Latinoam. Cien. Fisiol. Punta del Este 75-76, 1957
 

Described nucleolonema, a new cell structure

With Roberto J. Sotelo. Una nueva estructura celular: el nucleolonema. Rev. Fac. Hum. Cien. Montevideo 7:47-68,  
 

Created the concept of synaptic pathology    

Pathology of the interneuronal synapses. Excerpta Med. Intern. Congress Series 100:463-8, 1965
 
Discovered and described the trophic function of synapse (1956-8)
 
First to describe axo-axonic synapse
 

Demonstrated that Purkinje cells axons of cerebellum extend to nuclei of encephalic axis and spinal cord (1927)

 
Described accurately the morphological neuronal changes that characterize many neurodegenerative diseases
 
Showed how drugs modify the interneuronal connections
 
With chemist L.F. Fieser purified and synthesized gonyleptin from opilion Gonyleptus sp. (1955)
 
 

METHODS

Created endocardiac biomicroscopy

With Alberto Vaz Ferreira. Methode pour l’examen microscopique “in vivo” du coeur  dês vertébrés. Comp. Rend. Soc. Biol. Paris 106:847-50, 1931
 
Created bioiridomicroscopy