Venancio Deulofeu Gascons, Argentine organic chemist (Buenos
Aires 01 April 1902 – Buenos Aires 04 October 1984) ACHIEVEMENTS
Established
that bile of Argentine snakes displayed cholic acid
With
several coworkers determined composition of venoms from South American
toads Demonstrated the presence of adrenaline in anuran venom Developed a new type of delayed-action insulin Obtained the apocholic acid in Wieland’s laboratory Isolated stroma from urine independently from Swiss Hassler Isolated antibiotic curamycin from Streptomyces curacoi and elucidated its partial structure (1962) With Laughe isolated alkaloids saurin and sauroxine from Lycopodius sururus (1942) Elucidated structure of gamma-fagarine from Fagara coco, olivacine and guatambuine from Aspidosperma australe and tubulosine from Pogonopus tubulosus With G. Marini Bettolo characterized flavonoid glycosides from ombú (Phytolacca dioica) Characterized chlorogenic acids and related compounds from maté (Ilex paraguayensis) Isolated and characterized new natural sugar
derivatives as D-curacose, curacin and curamycose Isolated equine oestrogenic hormone (1934) Discovered new structural types in plant chemistry With A. Sordelli & R. Wernicke characterized Forssman antigen as a lipidic complex associated to a carrier protein Naturaleza del antigeno heterogenetico. Rev. Asoc. Med. Arg. 37:570, 1924 Sur la nature de l’antigéne hétérogénétique. C.R. Soc. Biol. Paris 92:898, 1925 Obtained new esthers of acids Nuevos esteres de los acidos bromopropionico y bromoisobutírico. Anal.Soc.Esp.Fis.Quim. 26:315, 1928 METHODS With Gimenez modified Wohl degradation by the use of propionylated nitriles With Sordelli developed a method for preparing insuline (Sordelli-Deulofeu method) in 1923 Developed a method for dosage of cholesterol in bilis Introduced picric acid for use in insuline precipitation and solvents and pure silk for its recovery Searched for general methods for transforming one aldose in another with exclusion of one carbon atom Developed a general method for N-methylated amino acids synthesis under aromatic aldehydes condensation with creatinine (1942) Eponym of Deulofeu-Mendivelzua method Papers in Nature With R. Labriola, O.Orias, E.M. de Españes & A.C. Taquini. Fagarine, a possible substitute for quinidine. Science 102(2638):69-70, 1945 With R. Labriola & B. Berinzaghi. Structure of alpha-fagarine. Nature 162(4122):694, 1948 With J.O. Deferrari. Preparation of D-glucose dibenzamide from pentabenzoyl-D-alpha-glucose. Nature 167 (4236):42, 1951
With F. Moewus. An antagonist of the sterility hormone rutin in the green alga Chlamydomonas eugametos: ombuoside=7,4’-dimethylrutin. Nature 173 (4396):218, 1954
HONORS Houssay Prize, Organization of American States Medal from International Academy of Lutetia Doctor Honoris Causa, Université de Paris (1955) |
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