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Sambhu Nath De

Sambhu Nath De, Indian physician (Hooghly District, West Bengal 15 February 1915 – Calcutta, West Bengal 15 April 1985)
Authored over 30 research papers

Developed an animal model for cholera using ligated intestinal loops in rabbits

With D.N. Chatterjee. An experimental study of the mechanism of action of Vibrio cholerae on the intestinal mucous membrane. J. Pathol. Bacteriol. 66:559-62, 1953


Discovered the cholera exotoxin

Enterotoxicity of bacteria free-culture filtrate of Vibrio cholerae. Nature 183:1533-4, 1959
Discovered the effect of this toxin on intestinal permeability


Medicine and Physiology Nobel Prize nominee