Eduardo Diego Patricio De Robertis, Argentine cytologist and microscopist (Buenos Aires 11 December 1913 – Buenos Aires 31 May 1988) Son of Italian immigrants ACHIEVEMENTS
With P. Rojas & F.A. Saez
discovered that most amphibians have no morphologically distinguishable sex
chromosomes (1935) Determinated the release mechanism of spermatozoa from amphibian male testicles Showed that gonadotrophin promotes
gonadal maturation in toads acting on Sertolli cells (1942) With Angel Pogo discovered follicular thyrocolloid or colloidal vesicles of thyroid gland Demonstrated the existence of an enzymatic
mechanism in production and reabsorption of thyroid hormone (1940s) First
demonstrated the existence of a thyroid protease With R.
Grasso demonstrated peroxidases in epithelial cells and proposed the benzidine
technique for histochemical localization of peroxidase activity (1946) With F.O. Schmit discovered neural
tubules or intracellular microtubules (1947) With B. Epstein & M. Reissig described contagious myxomatosis virus of rabbit (1952) With R. Canzani, B. Epstein & G. Gasic described mice transplantable leukemia virus (1955) With Bennett and independently from
Palade discovered synaptic vesicles in nerve terminals (1954) and named them With Bennett associated synaptic
vesicles to quantal acetylcholine and catecholamine release Demonstrated synthesis and release mechanisms in synaptic vesicles
Identified pre- and post synaptic receptors Identified the connective ciliary nature between the outer and inner segments of photoreceptors (1956)
With Lasansky first visualized
protein-lipid bilayers in retinal photoreceptors and myelin-sheath membranes
(1959) First described exocytosis mechanism in adrenal and the ontogenesis of photoreceptors Showed ultrastructure and
physiological role of synaptic vesicles (1967) With F. Wald & H. Gerschenfeld
discovered the role of glial cells in transmission of neural impulses With Pena, Medina, Novas & Paladini discovered N-butyl-β-carboline-3-carboxylate that binds to cerebral benzodiazepine receptors (1986) Coined term endomembrane system Developed techniques of subcellular
fractionation for nervous system studies With G. Rodríguez de Lores & A.
Pellegrino de Iraldi developed De Robertis method of differential
centrifugation for isolation of synaptic terminals (1962) Assay
of thyrotropic hormone in human blood. J. clin. Endocrinol. Metab.
8(11):956-66, 1948 With C.A. Peluffo invented a special
chamber to observe the motility of bacteria (1951) With A. Lasansky. Electron microscopy of retinal photoreceptors. The use of chromation following formaldehyde fixation as a complementary technique to osmium tetroxide fixation. J. Biophys. Biochem. Cytol. 7:493-8, 1960 With W. Nowinski & F.A. Sáez authored Citologia General or
Cell Biology (1946) with many issues Papers in top journals Absorption of the exocrine cells of the pancreas. Nature 157:264, 1946 With W.W. Nowinski. The mechanism of the therapeutic effect of iodine on the thyroid gland. Science 103 (2675):421, 1946 With E. Rodríguez de Lores Arnaiz & A. Pellegrino de Iraldi. Isolation of synaptic vesicles from nerve endings of the rat brain. Nature 194:794-5, 1962 With L. Salganicoff, L.M. Zieher & G. Rodríguez de Lores Arnaiz. Acetylcholine and cholinacetylase content of synaptic vesicles. Science 140(3564):300-1, 1963 Ultrastructure and cytochemistry of the synaptic region. The macromolecular components involved in nerve transmission are being studied. Science 156(3777):907-14, 1967 Molecular biology of synaptic receptors. Science 171(3975):963-71, 1971 With his son Eduardo Miguel De Robertis
authored Cell and Molecular Biology (1980) and translated into 9 languages Medicine & Physiology Nobel Prize nominee |
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