Hector Croxatto Rezzio, Chilean biochemist (Valparaiso
03 July 1907 – Santiago 28 September 2010) Authored over 300 works His works
on kalikrein-kynin system gained world acclaim Discovered pepsanurin (1942) and PU-D1, a new
kininogen-derived peptide With R. Silva, X. Figueroa, R. Albertini, J. Roblero & M.P. Boric. A peptide released by pepsin from kininogen domain 1 is a potent blocker of AMP-mediated diuresis-natriuresis in the rat. Hypertension 30(4):897-904, 1997 Showed that the proteolytic hydrolysis of plasma
proteins gave rise to potent peptides acting upon smooth muscles and kidney functions
With G.B.
Marini-Bettolo purified and characterized renal proteins presenting important
biological activity Described a
number of vasoactive peptides With J. Masferrer, R. Albertini, P. Garcia & I. Pinto. Isolation and characterization of rat plasma glandular kallikrein. Biochem. Pharmacol. 34(1):51-6, 1985
Eponym of Porcelli-Croxatto method for studying
urinary kallikrein (1970s) Papers in top journals With M. de la Lastra. Diurnal variations in ovarian ascorbic acid content of pseudopregnant immature rats used in Parlow’s test. Nature 208:789-90, 1965 With J. Arrau & H. Croxatto. Luteinizing hormone-like activity in human median eminence extracts. Nature 204:584-5, 1964 With M. de la Lastra. Ovarian ascorbic acid depleting activity in human brain extracts. Nature 204:583-4, 1964 With E. Labarca & G. Cofre. Effects od D,1-aldosterone on renal excretion of water, sodium, and potassium induced by renin. Nature 199:182-3, 1963 With J. Belmar. Hypertensive effects of bradykinin in rats. Nature 192:879-80, 1961 With T. Pereda & R. Mellada. Peptides with oxytocic and pressor activity obtained from acidified rat serum. Nature 184:1496, 1959 With F.B. Oberhauser, M.Q. Gaillard & M.V. Silva. Anti-tumorigenic action of iodinated compounds. Nature 176:466-7, 1955 With L. Barnafi. Anti-diuretic substances of the blood. Nature 172:304-5, 1953 With L. Barnafi, G. Rojas, A. Reyes & A. Infante. Anti-diuretic and oxytocic substances liberated by the digestion of plasmatic proteins with pepsin. Nature 171:82-3, 1953 With L. Barnafi & J. Passi. Effect of renin on diuresis in rats. Science 116 (3019):507-10, 1952 With G. Rojas & L. Barnafi. An antidiuretic substance obtained by digestion of globulin with pepsin. Science 113 (2939):494-5, 1951 With R. Croxatto & M. Reyes. The effect of hypertensin on the inactivation of oxytocin by the serum of pregnant women. Science 108 (2815):658-9, 1948 With R. Croxatto. Destruction of hypertensin and pepsitensin by an aminopeptidase obtained from yeast. Science 96 (2501):519-20, 1942 With R. Croxatto. Pepsitensin. A hypertension-like substance produced by peptic digestion of proteins. Science 95:1012, 1942 HONORS
Houssay Prize, OAS (1983) LINKS
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