Eduardo Cruz-Coke Lassabe, Chilean biochemist (Valparaiso
22 April 1899 – Santiago 18 March 1974) From French mother and English grandfather ACHIEVEMENTS
Developed the idea that molecular fluctuations exert a major influence on cells rather than that exerted by thermodynamics anticipating J. Monod Las transformaciones de la energia en
los organismos vivos. Rev. La Clinica
4:517-30, 1927 Discovered tyrosine molecule in angiotensin Identified a factor of “energy yield” in oxidation reactions Factores componentes del metabolismo. Rev. Med. Chile 68:159-62, 1940 With J. Mardones & M. Plaza de los Reyes proposed
a scheme of a number of biochemical reactions in renal hypertension mechanism METHODS Developed chemical methods for inactivating
angiotensin (1946) With L. Lapicque. Nouvelle methode de dialyse
chloroformique. Compt. Rend. Soc. Biol. Paris 96:946-8, 1927 Sur une reaction chimique de la vitamine
antirachitique. Compt. Rend. Soc. Biol. Paris 105, 1930 A colour reaction of vitamine E with vitamine K and
cysteine. Nature 181(4601):49, 1958 Papers in top journals With F. Gonzalez & W. Hulsen. The use of ionic exchange resins for the purification of penicillin and hypertensin. Science 101 (2622), 1945 (A simple method of purifying penicillin by means of synthetic resins) Inactivation of hypertensin. Science 104 (2691):86, 1946 Mechanism of renal hypertension. Ann. N.Y. Acad. Sci. 3:32-60, 1946 HONORS Doctor Honoris Causa, Université de Paris Life Member, New York Academy of Sciences Honorary Member, United States Surgeons Association Vice-president, First International Congress of
Biochemistry, Cambridge (1949) His son, Ricardo Cruz-Coke Madrid, Chilean physician (Santiago de Chile 13 August 1925 – Santiago de Chile 26 October
2016) Authored about 300 publications about medicine,
genetics, ethics and history Described a nomogram to estimate the chance of consanguinity for specific autosomal recessive diseases Nomogram for estimating specific consanguinity risks.
J. Med. Genet. 19(3):216-7, 1982 Sexagesimal scale for mapping human genome. Rev. Chil.
Hist. Nat. 74(1):91-7, 2001 A general diagram of human genome. J. Med. Genet. 27:388-9, 1990 With J.C. Silva. Medical genetic study by computer of a universal sample of livebirths. I. Introduction to the methods. Rev. Med. Chile 97(5):320-31, 1969 With J. Mardones. Detection of the segment of the population vulnerable to alcoholism, by means of a genetic marker Bol. Oficina Sanit. Panam. 71(3):187-93, 1971 Papers / Letters in Lancet Genetic diagram of the human family. Lancet 304 (7872):109, 1974 Genetic theory and the alcoholic phenotype. Lancet 302 (7840):276, 1973 With G.J. Gorrell & H.C. Thuline. Inheritance of alcoholism. Lancet 289 (7484):274-5, 1967 With A. Varela. Inheritance of alcoholism. Its association with colour-blindness. Lancet 2 (7476):1282-4, 1966 With A. Varela. Colour-blindness and alcohol addiction. Lancet 2 (7426):1348, 1965 Colour-blindness and cirrhosis of the liver. Lancet 1 (7396):1131-3, 1965 With R. Etcheverry & R. Nagel. Influence of migration on blood pressure of Easter Islanders. Lancet 1 (7335):697-9, 1964 Absence of essential hypertension. Lancet 278 (7214):1255, 1961 Environmental influences and arterial blood pressure. Lancet 2 (7156):885-6, 1960 The nature of hypertension. Lancet 275 (7134):1128, 1960 The nature of essential hypertension. Lancet 274 (7107):853, 1959 Diastolic pressure and malignant hypertension. Lancet 272 (7049):752-3, 1958
With M. Plaza de los Reyes, R. Orozco, I. Matus & A. Cristofanini. Influenzal pneumonia treated with cortisone and antibiotics. Lancet 270:7000-5, 1957 |
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