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Wilson Teixeira Beraldo

Wilson Teixeira Beraldo, Brazilian pharmacologist (Silvianopolis, Minas Gerais State 20 April 1917 – Belo Horizonte 28 July 1998)
 
ACHIEVEMENTS
Known internationally as an expert in vasoactive polypeptides (about 2,000 citations)
 

Co-discovered bradykynin

With M. Rocha e Silva & G. Rosenfeld. Bradykynin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiology 156:261-73, 1949.

Demonstrated bradykinin release in anaphylactic and peptonic shocks  
Formation of bradykinin in anaphylactic and peptone shock. Am. J. Physiol. 163(2):283-9, 1950 
 
Demonstrated urinary kallikrein is of renal origin 

Substance U: a depressor and smooth-muscle stimulating present in urine. Am. J. Physiol. 171(2):371-7, 1952


Demonstrated that granulations of mast cells store histamine 

With L.C.U. Junqueira, I. Mota e Albuquerque & R.G. Ferri. Intracellular distribution of histamine. Nature 174:698-9, 1954


Rat blood pressure as a diagnostic procedure for pheochromocytoma. Arch. Int. Pharmacodyn. Ther. 126:37-42, 1960 



Papers in top journals (see above) 

With M.R.E. Silva. Effect of cations upon recovery of the guinea pig gut from inhibition of antihistaminics. Science 108(2798):162-3, 1948

With L.C.U. Junqueira, I. Mota & A.G. Ferri. Action of peptone on mastcells of the dog. Nature 173:547, 1954

With O.B. Henriques & M. Fichman. Bradykinin-releasing fator from Bothrops jararaca venom. Nature 187:414-5, 1960 

With G. Gazzinelli, M.M. Guia, A.G. Neves, J. Pudles & W. da Silva. Purification of the toxic fractions from Ascaris lumbricoides and their effect on the guinea pig. Nature 190:813-4, 1961

 

MEMBERSHIP

Member, New York Academy of Sciences