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Ricardo Renzo Brentani

Ricardo Renzo Brentani, Italian-born Brazilian clinical biochemist (Trieste, Friuli-Veneza Giulia 21 July 1937 – São Paulo 29 November 2011)
 
Performed studies on cancer biochemistry and cytology
 
Authored about 200 papers with more than 5,000 citations
 
 

DISCOVERIES/METHODS

Demonstrated the presence of messenger RNA in nucleolus

With I. Raw & M. Brentani. Role of nucleolar ribonucleic acid in incorporation of ribosomal amino acid. Nature 201:1130, 1964

 

With G. Vignolas & L.C.U. Junqueira. A simple and sensitive method for the quantitative estimation of collagen. Anal. Biochem. 94:96-9, 1979
 

Developed Picrosirius polarization method or Junqueira staining

With G. Vignolas & L.C.U. Junqueira. Picrosirius staining of polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. Journal 11: 447-55, 1979
 

Demonstrated the collagen macromolecular orientation in basement membrane

With L.C.U. Junqueira, G.S. Montes, O.M.S.Toledo et al. Evidence for collagen molecular orientation in basement membranes. Histochem. J. 15:785-94, 1983 
 

Showed the presence of laminin receptors in membrane of pathogenic Staphylococcus

With J.D. Lopes & M. dos Reis. Presence of laminin receptors in Staphylococcus aureus. Science 229 (4710):275-7, 1985

 

With C.R.M. Barardi, C.L.S. Santos & L.L. Villa. A direct method for cDNA cloning employing translation-released mRNA. Brazilian Journal of Medical and Biological Research 20:313-320, 1987
 

With V. Martins, S. Souza & V. Moura Neto found that prion controls and organizes the information passing from outer to inner cell 

 

Papers in renowned magazines

With T. Maack & M. Rabinovitch. Increase in 'alkaline' ribonuclease of rat kidney cortex after lysozyme and egg-white administration. Nature (London) 186:158, 1960

With M.M. Brentani & I. Raw. Messenger RNA activity of RNA purified from rat-liver nucleoli. Nature (London) 7: 687, 1966.

With M.M. Brentani & I. Raw. Messenger activity of purified RNA from rat liver nuclei. Nature (London) 214:1122-1123, 1967

With H. Samaia, J.J. Mari, H.P. Vallada, R. Moura & A.J.G. Simpson. An Inherited Prion Disease With Prolonged Course And Psychiatric Onset. Nature (London) 390:241, 1997

 
 

PATENTS/INVENTIONS

With L. L. Villa. Vetores de transferência molecular contendo a informação para a síntese de pro-insulina humana e seus processos de obtenção (1983)

With S.J. de Souza. Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDs-page) which binds to prion protein. US 5679530 (1997)

With A.J.G. Simpson & E. Dias Neto. Method for determining nucleotide sequences using arbitrary primers and low stringency. US  0155438 (2002)

With A.J. G. Simpson & E. Dias Neto. Métodos para determinar sistemas abertos para leitura do genoma de um organismo, para determinar que uma seqüência de nucleotídeos conhecida a partir de um genoma de um organismo corresponde a uma sequência de nucleotídeos a partir de um sistema aberto para leitura, para preparar uma molécula de ácido nuclêico contíguo a partir de um genoma de um organismo, e para sequenciar todo ou parte de um genoma de um organismo US 0919671620 (2002) PI9900267-1 A2 (2002)