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Otto Guilherme Bier

Otto Guilherme Bier, Brazilian bacteriologist and immunologist (Rio de Janeiro 26 March 1906 - São Paulo 22 November 1985)
From German descent
Authored over 100 works
Performed important contributions on studies of antigen-antibody reactions and complement system

With M. Siqueira found that antigen-antibody complexes can act even at the site of passive cutaneous anaphylaxis reactions evoked by unrelated antigen-antibody systems

Hemorrhagic reactions at sites of passive cutaneous anaphylaxis in guinea pig after intravenous inoculation of unrelated immune complex. Proceed. Soc. Exper. Biol. Med. 107(4):779-84, 1961  

With M. Siqueira & G. Biozzi observed that immunological competence develops eventually, even in bursectomized animals, albeit with a considerable delay in time 


Codescribed Pacheco disease in Psittacidade birds (1929)

Pacheco, G., Bier, O. Epizootie chex lês perroquets du Brésil. Relations avec Le psittacose. C.R. Séance Soc. Biol. 105:109-111, 1930.

Showed that Bothrops venom displayed inactivant action on fourth component of complement system

Uber Komplement-inativierung durch Bothropsgift (B. jararaca). Zeitschr. F. Immunit. 11:187-94, 1932 


Described serovar Salmonella butantan with Amaral, Peluffo & Biocca 1946

Described the biological role of antibodies on glomerulonephritis

With H.C. Passos, O.C. Martínez & M.S Pinheiro. Studies on the nephrotoxic activity of guinea-pig gamma 1 and gamma2 antibodies. Immun. 26(2):407-16, 1974


With R. Binaghi, M. Akashi & E. Avelar Naves. Mechanism of anaphylactic desensitization in guinea pigs. Rev. Fr. Allergol. 9(4):246-50, 1969

With C. Stiffel, A. Perini, H.C. Passos & G. Biozzi. Role of the bursa of Fabricius and the thymus in the synthesis of opsonin type antibodies. Pathol. Biol. 16(1):67-72, 1968

With M. Rocha e Silva & M. Aronson. Histamine release by anaphylatoxin. Nature 168(4272):445-6, 1951

With N. Planet. Sur la presence d’un facteur qui augmente la permeabilité papillaire dans les extraits de peau normale. C.R. Soc. Biol. 129:65, 1938



With M.S Pinheiro & R.S. Furlanetto. Amboceptor titration as a statistically controlled assay. J. Immunol. 69(3):241-6, 1952

With M.S Pinheiro & R.S. Furlanetto. Quantitative complement fixation in syphilis as a statistically controlled assay. J. Immunol. 74:51-6, 1954

With M.S Pinheiro, M.B. Esteves & P.M.Freire. Quantitative relations in complement fixation. Amer. J. Epidem. 89(3):353-7, 1969

With M.M. Mayer, A.G. Osier & M. Heidelberger. Quantitative studies of complement fixation. I. A method. J. Immunol. 59:195, 1948  

With R. Furtado & E. Cisalpino. A plate technique for the conglutinative complement fixation test. Proc. Soc. Exptl. Biol. Med. 95:335-9, 1957.

With M. Siqueira & M.B. Esteves. Quantitative studies of complement fixation. I- A simplified and accurate procedure based on 50 per cent hemolytic end point. Rev. Inst. Med. Trop. São Paulo 10:199-208, 1968.   

With I. Mota, W. Dias da Silva and N. Vaz, published Imunologia Básica e Aplicada (Fundamentals of  Immunology), translated into English and German languages (1973)   

Bieria Leão 1940 (Trematoda)