Cássio Bottura, Brazilian cytogeneticist and hematologist (Matão, São Paulo State 20 January 1920 – Ribeirão Preto, São Paulo State 26 January 1988)
Published nearly 60 works
Co-authored the first publication reporting a megaloblastic change that complicated the course of hemolytic anemia in sickle cell anemia (1944), 8 years ahead international literature
Introduced the use of glycose and insulin for the treatment of acute alcoholism
With D. Pfuhl Neves & L. Marques de Assis. Tratamento do alcoolismo pela glicose e insulina. Rev. Paul. Med. 32:226-7, 1948
Developed original techniques for the investigation of the cytogenetics of neoplastic diseases of the blood
Developed a direct technique for analysis of human chromosomes from cells of bone marrow
With I. Ferrari. A simplified method for the study of chromosomes in man. Nature 186:904-5, 1960
Described spontaneous chromosome endoreduplication in acute leukemia
With I. Ferrari. Endoreduplication in acute leukemia. Blood 21:207, 1963.
Observed chromosome abnormalities in patients treated with pyrimethamine, suggesting that such anomalies may also occur in megaloblastic anemia
With V. Coutinho. Pyrimethamine (Daraprim) induced chromosome abnormalities in man. Human Chrom. Newsl. 15:4, 1965.
Demonstrated the clonal nature of cell proliferation in Waldenstrom’s macroglobulinemia
The genetic nature of Waldenstrom’s macroglobulinemia. Prensa Med. Argentina 53:223-4, 1966 (in Spanish)
Demonstrated that the Philadelphia 1 chromosome in chronic myeloid leukemia originates from reciprocal translocation
With V. Coutinho. A possible explanation for the origin of the Philadelphia chromosome. Blur 22:273-6, 1971.
Most of this text was extracted from Rev. Bras. Genet. (Brazil. J. Genetics) 11(2):493-4, 1988.