With R. Lucio described a form of lepromatous leprosy with diffuse infiltration of skin and without nodules known as diffuse leprosy of Lucio-Alvarado-Latapí or simply Lucio leprosy

With R. Lucio described necrotizing erythema seen in Lucio leprosy known as Lucio phenomenon

Opusculo sobre el mal de San Lazaro ó elefancíasis de los griegos (1851)

Created a prophylactic procedure for syphilis