Donato Alarcón Segovia, Mexican physician (Ciudad de
Mexico 06 May 1935 – Ciudad de Mexico 21 December 2004) Authored over 300 papers, 14 books and 99 book
chapters World Pioneer on studies of immune regulating circuits
and analysis of pathogenic role of antinuclear and anti-phospholipids antibodies
With D.G. Alarcón reported the first detailed
description of pleuropulmonary manifestations of systemic lupus erythematosus
(1961) Studied lupus drug-induced syndromes, described its
clinical aspects and auto antibodies that feature it (1969) First to suggest that antinuclear
antibodies could be natural antinuclear auto antibodies (1970) before Avrameas With A. Ruiz Arguelles & E.
Fishbein first described antibodies penetration in living cells and its
functional consequences in Nature 271:67-9, 1978 With F. Ramos Niembro, R.P. Tamayo
& J. Alcocer proposed the use of colchicine for treatment of sclerodermia
(1979) With J. Alcocer described cytokines
relationship to a disease in J. Clin. Investig. (1981) Performed the first studies about
nuclear medicine application to rheumatic studies disease With A.E. Gharavi first described
primary variety of antiphospholipid syndrome (1989) With Harris described the criteria
of antiphospholipid syndrome Imagined the bone gammagraphy
technique Eponym of Alarcón Segovia diagnostic
criteria for mixed connective tissue disease and Alarcon-Brown classification
for nectrotizing vasculitides Held about 10000 citations LINKS http://reumatologiaclinica.org/es/in-memoriam/articulo/13075522/ (in Spanish) |
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